Louis de Fumel (1700-1749). He became the Lord of Haut-Brion after the death of his mother. His time was short lived however, as he died one year after taking charge.

Joseph de Fumel (1720-1794). After his father's untimely death in 1749, Joseph, the third son, inherited the domain. In 1748, he married Marie-Elisabeth de Conty d'Hargicourt. Although first a soldier, Joseph became the master of Haut-Brion in 1763.

He designed a large park and added an orangerie along with several other buildings.

Joseph developed the wine trade abroad. He sent much wine to England, his first foreign market. At this time, the French were becoming increasingly appreciative of the "vin de Pontac": it was during this period that the Duke de Richelieu introduced the King to Haut-Brion.

The beginnings of the Revolution had little effect on the domain. Fumel gave his renowned Château Trompette to the people of Bordeaux but his gold and silver went to the government. His foreign commercial links, especially with England, and the emigration of some of his family made him suspicious to the revolutionaries. In the end, he was arrested and guillotined.

Haut-Brion then fell on difficult times. Sold as a national asset, it subsequently passed through several hands. Finally, in 1801, the Prince de Talleyrand purchased it.